Search
 
 
Administration
Introduction
Organization
Faculty and Staff
Academic Committee
 
Research Focus
Implants and Biomechanics
Cell and Gene Therapy
Biomaterials
Musculoskeletal Aging and Bone tumor
 
Technology Platforms
Biomechanical Testing and Platform Analysis
Hard tissue Sections and Bone Histomorphometry
Cell and Molecular Biological Study
Bone Microstructure Analysis and BMD Test
Public Service

 
 
Collaborating Center for Orthopaedic Translational Research
 Contact  |  Home |  中文版
Home About us Research Highlights Education Publication
 
Targeting Osteocytes to Attenuate Early Breast Cancer Bone Metastasis by Theranostic Upconversion Nanoparticles with Responsive Plumbagin Release
The diagnosis and treatment against breast cancer bone metastasis in early stage remain a great challenge clinically. Recently, ACS Nano (IF=13.96) published relevant research results by Prof. Tingting Tang group in Shanghai Ninth People’s Hospital; Ph.D. student Han Qiao was the first author. The group developed a pH-responsive bone-targeting drug nanocarrier, namely zoledronic acid (ZA)-anchored plumbagin (PL)-loaded Gadolinuim (Gd)-doped upconversion nanoparticle (PUCZP). This study showed that such theranostic nanoplatform was capable of diagnosing tiny breast cancer bone lesions in early stage as well as releasing curing drug against osteocytes to attenuate breast cancer bone metastasis. PUCZP could target osteocytes to suppress the expressions of osteocytic RANKL and Sclerostin, thereby inhibiting osteoclastogenesis and osteolysis. Also, the combination of PL with active ZA in PUCZP could simulate the structure of ANP to compete its binding with PKa and CREB, hence downregulating the expression of osteocytic RANKL. This work was the collaborative result of Orthopaedic Department in Shanghai Ninth Hospital together with Prof. Wenbo Bu in East China Normal University and Prof. Xiaopeng He in East China University of Science and Technology. This work was funded by the National Key R&D Plan (2016YFC1102100), National Natural Science Foundation of China (81672205) and the Innovation Program for PhD students in Shanghai Jiaotong University School of Medicine (BXJ201729). (Qiao H, Cui Z, Yang S, Ji D, Wang Y, Yang Y, Han X, Fan Q, Qin A, Wang T, He XP, Bu W, Tang T. Targeting Osteocytes to Attenuate Early Breast Cancer Bone Metastasis by Theranostic Upconversion Nanoparticles with Responsive Plumbagin Release. ACS Nano. 2017 Jul 25; 11(7): 7259-7273. doi: 10.1021/acsnano.7b03197)
Bulletin    
Prof. Tingting Tang was newly elected as the vice Chairman of basic research committee of Chinese Association of Orthopaedic Surgeons (CAOS)
Academician Kerong Dai and Prof. Tingting Tang were elected ICORS Emeritur Fellow and ICORS-Fellow, respectively
Congratulations to Dr. Qiming Fan and Dr. Xiuguo Han from Shanghai Ninth People’s hospital for receiving Best Poster Award and Best Paper Recognition Award in 2016 ICORS
Department of Orthopaedics, Shanghai Ninth People’s Hospital won 3 programs of the national key research and development plan in 2016, with a total fund of 33.7 million.
Professor Tingting Tang will serve a 3-year term editorial member of Journal of Bone and Mineral Research

   
 
 
Implants and Biomechanics  
 
 
Development and application of new orthopedic implants such as the customized prosthesis and fracture fixator
Implant related biomechanical analysis and biomedical engineering
Musculoskeletal mechanobiology
 
Biomaterials  
 
Development and evaluation of functional bone substitutes
Surface modification of orthopaedic implants
Osteolysis mechanism and prevention of implant associated infections
 
 
Cell and Gene Therapy  
 
Cell and gene therapy for bone and cartilage repair
Tissue engineering and bioreactors
Regulation mechanism of adult stem cells differentiation
 
Musculoskeletal Aging and Bone Tumor  
 
Bone metabolism and osteoporosis
Cartilage metabolism and Osteoarthritis
Bone tumors and microenvironment
Shanghai Key Laboratory of Orthopaedic Implants
Copyright © 2013 www.ortholab-snph.com All rights reserved.
Address: 639 Zhizaojiu Road, Shanghai 20001 Tel:(021)23271133 Fax: (021) 63137020 E-mail:shengwulixue@gmail.com