Shanghai Key Laboratory of Orthopaedic Implants is the research base of Orthopedic Department, Shanghai Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine. Founded in 1986 by Prof. Ke-rong Dai, the lab was one of the earliest institutions that carried out biomechanical researches on musculoskeletal system, and it was enlisted in Shanghai key laboratory construction plan in Oct 2008. For years of development, the lab has become an influential R&D center of orthopedic implants and training base at home and aboard, and it is also responsible for editing Journal of Medical Biomechanics, the only one biomechanics journal in China. Headed by Academician Ke-rong Dai, Prof. Ting-ting Tang and Prof. Zhen-an Zhu, the lab owns an academic research team comprised of orthopedic surgeons, full-time researchers, engineers and technicians, featuring its cross-disciplinary research in medicine and engineering. Meanwhile, the lab is an important training base of post-doctors, doctors, and masters for Orthopedic Department of Shanghai Ninth People’s Hospital, which is currently the construction unit of State Key Discipline, National Clinical Key Specialty, National “211 Project” Key Discipline, Shanghai Clinical Medical Center of Joint Surgery and Key Discipline of Shanghai Education Commission.
At present, the lab has formed the organizational structure of “one body two wings”. The main “body” of the lab, located in Shanghai Ninth People’s Hospital, focuses on clinical-oriented translational researches, forming several technical platforms in biomechanical analysis on musculoskeletal system, bone microstructure observation and bone histomorphometric analysis, and cellular and molecular biology research. One “wing” is Laboratory of Orthopedic Cellular and Molecular Biology, located in Institute of Health Sciences, Chinese Academy of Sciences, which mainly carries out orthopedics-related basic researches, such as induced differentiation of stem cells, interaction of materials and cells, etc. The other “wing” is Engineering Research Center of Digital Medicine and Clinical Translation, Ministry of Education, located in Xuhui Campus of Shanghai Jiao Tong University, which mainly carries out researches on implant-related key problems and key technology in digital medicine and serves as the pre-production and industrial base of orthopedic implants such as individualized prosthesis.
The lab has been actively carrying out clinical-oriented medical researches on orthopedic translation, with great achievements in optimization design and application of artificial joint, stem-based therapy for bone repair and regeneration, development and evaluation of functional bone substitutes, mechanism and prevention of periprosthetic osteolysis, osteoporotic fractures, and fracture healing, etc. The lab also emphasizes the translation and clinical application of scientific findings. The individualized artificial joints and bone allograft had been approved by SFDA for the industrialization and clinical application. Clinical trial had demonstrated that the enriched stem cells from bone marrow could promote spinal fusion and treat the bone nonunion.
The lab has active collaborations with first-class research institutes and scientists home and abroad. Established collaborating centers include the Sino-French Research Laboratory of Biomaterials and Cell Therapy, the Collaborating Orthopedic Translating Research Center with ICHTS (International Chinese Hard Tissue Society). The lab also provides technique service and support for other research institutes and enterprises in Shanghai through establishing open projects, receiving visiting researchers, joint R&D, etc.
During the year 2010-2014, the lab has acquired 103 grants with the total funds of 453.3 million yuan, including 2 subprojects supported by the National 973 Program, 28 projects (with 1 key project ) supported by the National Natural Science Foundation of China. The lab also wins the Second Prize for Science & Technology Development/Achievement of the Ministry of Education of China, and the Third Prize of Shanghai Science and Technology Progress Award. The lab has applied or acquired 72 national invention, utility, design patents, of which 31 have being authorized. The lab has published over 300 papers in international and domestic journals, 191 of which are included by SCI or EI. In 2014, the number of published SCI papers is 57. In terms of talent training, the lab has received funding at municipal level or above, such as Program for New Century Excellent Talents in University, New Century Hundred, Thousand, Ten Thousand Talent Project, Shanghai Cultivation Program for Academic Leaders, Shanghai Science and Technology Committee Rising-Star Program and Rising-Star Tracking Program, Shanghai Pujiang Talent Program, Shanghai Dawn Program and Dawn Tracking Program, China Scholarship Council Program for Constructing High-level Universities, etc. During the 5 years, 33 PhD students, 32 postgraduate students and 5 postdoctoral students have been recruited and trained in the lab.